Scientists uncover key new molecules that could help to tackle tooth loss and regeneration

New research published in the Journal of Dental Research has shed light on the science behind the formation of the periodontal ligament, which helps keep the tooth stable in the jawbone. This improved understanding will help scientists work towards regenerating the tissues that support teeth. This is a peer-reviewed, observational study conducted in rodent teeth and human cells.

The study, led by the Universities of Plymouth and Geneva, shows how a signalling pathway* called Notch, which is known to be activated in stem cells and cancer, is important for periodontal ligament development.

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